Familiar symptoms of diabetic neuropathy comprise burning pain and paralysis typically in the feet. The behavior of animals can be used as a model to substantiate the extent of neuropathy and its response to treatment. However, the aetiology of these disturbances is still unknown, although metabolic factors such as hyperglycemia or neurotransmitter alterations may be involved. The abnormalities seen the nerves of diabetic patients seem to be associated to fluctuations in a cellular enzyme known as Pkc or Protein Kinase C. In the involved scheme of power creation in the cell, a chemical known as Atp is broken down and contributes a hi power phosphate molecule, Protein Kinase C, is an enzyme responsible for this reaction.
This whole process, removing a phosphate molecule and transferring it to a protein, is called phosphorylation. The goal of this reaction is to whether switch on or deactivate assorted metabolic pathways. There are many diverse forms of Pkc, the one that appears most relevant to our conference of diabetic neuropathy, appears to the Pkc isoform Beta. Available study suggests that Pkc~Beta appears to be the over-active form of Pkc in diabetic patients. an additional one line of evidence supports the involvement of Pkc in diabetic neuropathy. Drugs that block this enzyme ameliorate diabetic complications. Nerves comprise both calcium and sodium channels that are accountable for their function. It appears that Pkc, interacts with these channels and this interaction is at least partially responsible for the symptoms of pain and paralysis in diabetic patients. Further study suggests that Pkc activation brings forth hyperexcitability in exact nerve fibers associated to pain, the so called C-fibers. Activation and hyperactivity of pain carrying (C-fibers) is believed to organize many of the painful symptoms in patents with neuropathy. A estimate of studies protein kinase inhibitors and their effects on both nerve function and the signs and symptoms of neuropathy are appearing the scientific literature.
Vitamine
Interestingly, chemicals that block Pkc, have the ability to cut the volatility in damaged nerves in animals suffering from experimentally induced neuropathy. Blocking the Cpk enzyme produces minute or no ensue on the function of general nerves from control animals. This property, the normalizing of nerve function, occurred in a dose-dependent manner. That means the higher the dose of the Pkc inhibitor, the more normalization of nerve function occurred. This and similar experiments, seem to indicate that the Pkc enzyme plays an vital role in the development of the intense nerve pain of neuropathy and that agents that can block this enzyme can tone down or modulate the over-excited nerves that carry pain signals in neuropathy patients.
To Further hold the link between Cpk and the nerve complications in diabetes, other experiments demonstrated that drugs that enhance the activity of Pkc genuinely will yield or aggravate the nerve abnormalities associated with diabetes. Thus the current experimental data implies that Pkc activation will aggravate and Pkc inhibition will ameliorate the abnormal nerve activity found in diabetes. Extra nerve tests known as nerve conduction studies, also confirm the contention that Pkc is associated to nerve function and neuropathy. These nerve conduction study tests show that activation of Pkc leads to enduring enhancement of electrical activity in a part of the spinal cord called the dorsal horn. The dorsal horn functions to carry sensation, together with pain from the body to the brain. From all this data, one could surmise that activation of Pkc in diabetic nerves explains at least in part, the development irritating neuropathy. Currently there are a estimate of drugs under development that are designed to block or decrease the activity of the Pkc enzyme and lighten neuropathic pain. The practitioner of Integrative Neurology might propose naturally occurring Pkc inhibitors as alternatives to drugs. Let's take a look at some natural substances that may serve as efficacious Pkc enzyme inhibitors.
At this point in our discussion, I must issue a disclaimer: The information I am about to gift to you is not intended to replace the hint given by a licensed healthcare provider. Natural therapies are usually safe, but you may be allergic or otherwise intolerant of them.
Furthermore they can and do interact with other natural and prescription medications. All the time consult your doctor before adding or changing your medicine plan. So only use this information in conjunction with a licensed healthcare practitioner. Gink Biloba: Ginko is one of the most widely used herbs. It is often taken to help with memory problems and to increase circulation. One of the therapeutic properties of Ginko may be associated to its ability to suppress the activation of Pkc enzymes. Which at least in theory, suggests it might be useful for patients suffering from neuropathy. Egb 761 is a Ginko derivative, that appears to block the Pkc enzyme. This ability may in part interpret Ginko's purported ability to protect nerves and neurons. an additional one study supported these findings, the authors discontinue that the ginko derivative, Egb 761 protects the nerves and brain via Pkc inactivation. Taken together, these results hold the hypothesis that dietary intake of natural substances that may inhibit the activation of Pkc, may be useful in general aging of the brain. Vitamin E: This vitamin has a long historical use in the arresting of heart disease and atherosclerosis. The mechanism of activity of vitamin E may be associated to its ability to antagonize the activation of the Pkc enzyme.
Further, studies show that high doses of vitamin E were able to decrease the level of Pkc induced by diabetes or continued high blood sugar. Thus animal and clinical studies have shown that high doses of vitamin E medicine can apparently reverse some of the complications seen in association with diabetes and high blood sugar. The apparent health benefits of vitamin E in diabetes are associated to its ability to suppress Pkc activation. So in diabetic patients, without contraindications or known sensitivity to Ginko and Vitamin E, the increasing of these two nutrients to their appropriate diabetic administration agenda may reduce, slow or even reverse some of the complications of high blood sugar together with neuropathy.
Always consult your doctor before adding or changing your diabetes administration program.
Do Ginko and Vitamin E Have a Role in administration of Diabetic Neuropathy?
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