Familiar symptoms of diabetic neuropathy comprise burning pain and dullness typically in the feet. The behavior of animals can be used as a model to substantiate the extent of neuropathy and its response to treatment. However, the aetiology of these disturbances is still unknown, although metabolic factors such as hyperglycemia or neurotransmitter alterations may be involved. The abnormalities seen the nerves of diabetic patients seem to be linked to fluctuations in a cellular enzyme known as Pkc or Protein Kinase C. In the complicated task of energy creation in the cell, a chemical known as Atp is broken down and contributes a hi energy phosphate molecule, Protein Kinase C, is an enzyme responsible for this reaction.
This entire process, removing a phosphate molecule and transferring it to a protein, is called phosphorylation. The goal of this reaction is to whether switch on or deactivate varied metabolic pathways. There are many diverse forms of Pkc, the one that appears most relevant to our conference of diabetic neuropathy, appears to the Pkc isoform Beta. Available study suggests that Pkc~Beta appears to be the over-active form of Pkc in diabetic patients. Other line of evidence supports the involvement of Pkc in diabetic neuropathy. Drugs that block this enzyme ameliorate diabetic complications. Nerves comprise both calcium and sodium channels that are accountable for their function. It appears that Pkc, interacts with these channels and this interaction is at least partially responsible for the symptoms of pain and dullness in diabetic patients. Added study suggests that Pkc activation brings forth hyperexcitability in definite nerve fibers linked to pain, the so called C-fibers. Activation and hyperactivity of pain carrying (C-fibers) is believed to organize many of the painful symptoms in patents with neuropathy. A whole of studies protein kinase inhibitors and their effects on both nerve function and the signs and symptoms of neuropathy are appearing the scientific literature.
Vitamine
Interestingly, chemicals that block Pkc, have the quality to cut the volatility in damaged nerves in animals suffering from experimentally induced neuropathy. Blocking the Cpk enzyme produces microscopic or no supervene on the function of general nerves from control animals. This property, the normalizing of nerve function, occurred in a dose-dependent manner. That means the higher the dose of the Pkc inhibitor, the more normalization of nerve function occurred. This and similar experiments, seem to indicate that the Pkc enzyme plays an vital role in the development of the intense nerve pain of neuropathy and that agents that can block this enzyme can tone down or modulate the over-excited nerves that carry pain signals in neuropathy patients.
To Added withhold the link in the middle of Cpk and the nerve complications in diabetes, other experiments demonstrated that drugs that heighten the activity of Pkc authentically will furnish or aggravate the nerve abnormalities linked with diabetes. Thus the current experimental data implies that Pkc activation will aggravate and Pkc inhibition will ameliorate the abnormal nerve activity found in diabetes. Extra nerve tests known as nerve conduction studies, also confirm the contention that Pkc is linked to nerve function and neuropathy. These nerve conduction study tests show that activation of Pkc leads to enduring enhancement of electrical activity in a part of the spinal cord called the dorsal horn. The dorsal horn functions to carry sensation, including pain from the body to the brain. From all this data, one could imagine that activation of Pkc in diabetic nerves explains at least in part, the development irritating neuropathy. Currently there are a whole of drugs under development that are designed to block or decrease the activity of the Pkc enzyme and lighten neuropathic pain. The practitioner of Integrative Neurology might suggest plainly occurring Pkc inhibitors as alternatives to drugs. Let's take a look at some natural substances that may serve as efficacious Pkc enzyme inhibitors.
At this point in our discussion, I must issue a disclaimer: The facts I am about to present to you is not intended to replace the advice given by a licensed healthcare provider. Natural therapies are usually safe, but you may be allergic or otherwise intolerant of them.
Furthermore they can and do interact with other natural and prescribe medications. Always consult your doctor before adding or changing your medicine plan. So only use this facts in conjunction with a licensed healthcare practitioner. Gink Biloba: Ginko is one of the most widely used herbs. It is often taken to help with memory problems and to increase circulation. One of the therapeutic properties of Ginko may be linked to its quality to suppress the activation of Pkc enzymes. Which at least in theory, suggests it might be useful for patients suffering from neuropathy. Egb 761 is a Ginko derivative, that appears to block the Pkc enzyme. This quality may in part expound Ginko's purported quality to safe nerves and neurons. Other study supported these findings, the authors finish that the ginko derivative, Egb 761 protects the nerves and brain via Pkc inactivation. Taken together, these results withhold the hypothesis that dietary intake of natural substances that may inhibit the activation of Pkc, may be useful in general aging of the brain. Vitamin E: This vitamin has a long historical use in the stoppage of heart disease and atherosclerosis. The mechanism of activity of vitamin E may be linked to its quality to antagonize the activation of the Pkc enzyme.
Further, studies show that high doses of vitamin E were able to decrease the level of Pkc induced by diabetes or prolonged high blood sugar. Thus animal and clinical studies have shown that high doses of vitamin E medicine can apparently reverse some of the complications seen in connection with diabetes and high blood sugar. The apparent condition benefits of vitamin E in diabetes are linked to its quality to suppress Pkc activation. So in diabetic patients, without contraindications or known sensitivity to Ginko and Vitamin E, the increasing of these two nutrients to their accepted diabetic management schedule may reduce, slow or even reverse some of the complications of high blood sugar including neuropathy.
Always consult your doctor before adding or changing your diabetes management program.
Do Ginko and Vitamin E Have a Role in management of Diabetic Neuropathy?
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