Based upon data from the Framingham Offspring Study based out of Harvard medical School, it is clear that there is an epidemic Vitamin D scantness that may growth the risk of heart disease. (A subject for another article; as well as referenced below in prior "updates.") However, few people are aware that there is also a serious epidemic scantness of vitamin E. An editorial that accompanied the largest study on vitamin E in medical history (Am J Clin Nutr 2006 Nov;84(5):1200-7) stated 93% of American men and 96% of American women do not collect the [pathetically low] recommended dietary discount of 15 Iu of vitamin E per day.
It is clear that we should be taking at least 30 to 50 times that level (400 to 1000 Iu/day) to sell out the risk of continuing diseases. Taking this much vitamin E in the accurate form and equilibrium with other vitamins, is both safe and effective; more than the pharmaceutical clubs would have you believe. However, it is in the economic interest of pharmaceutical clubs to dissuade the group from taking supplements so that they can be on medications which often do minute to nothing to reverse disease. Other condition practitioners make their living by "educating" others that they can get everything they need from their food alone. The medical investigate indicates otherwise. The whole of vitamin E, as well as other foremost vitamins, required to sell out the risk of continuing diseases can only be obtained straight through supplementation.
Vitamine
Tragically many doctors and the lay person have the misconception that vitamins, such as vitamin E supplementation may be harmful. There seems to be continued misinformation put out in news media and condition magazines, about the "dangers" of supplementation. Either they are not aware of the medical research, or they are purposefully misleading the group for their own gain. This non-stop endeavor to persuade people not to supplement, but to get all their antioxidants from their food alone is at minimum unethical, at worst dangerous. Vitamin E seems to be in these detractors line of fire more than any other nutrient, probably because it is the most base supplement used today. With the thousands of medical studies showing the benefits of supplemental vitamin E, how is it that there is still controversy and confusion? The doses of vitamin E that investigate has shown to be of benefit can Only be obtained straight through permissible supplementation.
Almost weekly a new study about the benefits of vitamin E is published. Almost all show condition benefits or inherent condition benefits. Because vitamin E is one of the most favorite supplements, it is only when a medical study or narrative showing a inherent negative consequent it is reported by the media, Either to make headlines, and/or to scare people away from taking this foreseen, vitamin. The negative findings about vitamin E of a few medical reports have Either shown to be excessively biased, restricting other foremost vitamins that work synergistically with vitamin E, poorly designed, or bearing no cause and consequent of vitamin E to a detrimental condition impact. The studies of vitamin E that have shown a true inherent negative impact are few, but of more significance it has given us clarity about the synergistic impact of varied vitamins as well as the significance of the formulation of vitamin E.
Vitamins must work together for optimal benefit:
Studies published many years ago showed that for vitamin E to continue to function as an antioxidant within the body, enough levels of vitamin C must be gift to regenerate (donate more electrons) to vitamin E so that it can continue to forestall oxidation of lipids. Any study about vitamin E that restricts the participants from also taking vitamin C is setting up the study to show nothing more than how vitamin E is swiftly "used up," and not regenerated to continuously provide an antioxidant benefit. It tells us nothing about the real benefits that can be obtained from permissible supplementation.
The accurate formulation of vitamin E is critical:
Vitamin E is a family of nutrients; alpha, delta, and gamma-tocopherols and tocotrienols. There is a distinction between the artificial (petroleum-derived) vitamin E, dl apha-tocopherol , and the natural (food-based ) vitamin E, d alpha-tocopherol. Gamma-tocopherol is a significant form of vitamin E needed to sell out the oxidation of lipids (cholesterol) in conjunction with alpha-tocopherol. (J Am Copll Cardiol. 1999 Oct:34(4):1208-15, Pro Natl Acad Sci Usa, 1993 Mar 1:90(5):1771-5) In addition, studies have shown that people who supplement solely with vitamin E in the alpha-tocopherol form are at risk to lower the blood levels of a significant form of vitamin E, gamma-tocopherol. (J Nutr. 2003 Oct:133(10):3137-40; J Nutr.1985 Jun:115(6):807-13 ) The midpoint American's blood-stream is five times more rich in alpha-tocopherol than gamma-tocopherol, and that distinction jumps 20-fold among people who take vitamin E as alpha-tocopherol without gamma tocopherol.
In 2007, a negative study about vitamin E (that lingers as the "justification" for the case against vitamin E) highlights the way the group can be mislead to make some poor decisions about supplementation. (Jama Feb 27, 2007). This was a flawed study with flawed data that ended that vitamins A and E "significantly increased the risk of mortality." This meta-analysis (report) did very minute to help us understand the benefits of vitamin E, but showed us just how data, and the public's opinion, can be manipulated. The authors of this meta-analysis (which is not a study per se, but a impart of former published studies) considered 815 prior studies about antioxidants, but included the results of only 68 of these studies for analysis. Some of the studies excluded from their narrative showed significant benefits and discount of mortality from taking supplements. Option bias was glaringly evident. The authors essentially "cherry-picked" the studies they wanted, and ignored others, so that they could come to their desired conclusion: vitamin E can kill you!
The authors were unable to construct any cause and consequent between supplementation with vitamin E and an increased risk of death, production this a poorly designed study. The elderly people who died could have just as legitimately died from accidents, medications, surgery, etc. ...who knows? One noted researcher described this narrative a kin to "doing a cholesterol-lowering study without ever measuring cholesterol levels." Furthermore, the midpoint period of the reviewed studies was 2.7 years, so the ridiculous closing that the authors wanted the group to believe was that vitamin E could kill you (somehow) in less than 3 years!
The others ignored many studies showing significant benefits derived from supplemental vitamin E. One such study that was ignored by these researchers was the November 10, 2006 study published in the American Journal of Clinical nourishment which is the largest study on vitamin E in medical history measuring alpha-tocopherol in male smokers. (Am J Clin Nutr 2006 Nov;84(5):1200-7) This study followed 29,000 patients for over 19 years, and included over 13,000 deaths, ...making inherent a significant and fair pathology of vitamin E and the risk of death.
This study showed a significant discount in extensive mortality in those patients with the highest blood levels of alpha-tocopherol. Specifically, over a 19-year period men with the highest blood levels of alpha-tocopherol showed the following discount in causes of death:
" Prostate Cancer 32% discount of Death
" Ischemic Stroke 37% discount of Death
" Hemorrhagic Stroke 35% discount of Death
" Lung Cancer 21% discount of Death
" Respiratory Illness 42% discount of Death
The authors of this significant and noteworthy study stated: "As a traditional fat-soluble antioxidant that protects lipids from peroxidation, alpha-tocopherol is able to scavenge mutagenic free radicals and inhibit the oxidation of Ldl-cholesterol, and the abilities have foremost implications for the prevention of carcinogenesis and atherosclerosis ....alpha-tocopherol also has any foremost functions that are independent of its antioxidant activity, including modulation of gene expression, enhancements of immune responses , an suppression of tumor angiogenesis."
The researchers further elaborated that although the patients who enjoyed the many condition benefits had higher blood levels of alpha-tocopherol, these same subjects also had the highest levels of gamma-tocopherol, meaning that these people were taking the natural formulation of vitamin E, not dl-alpha-tocopherol without gamma-tocopherol and the tocotrienols. This study, and other significant studies are ignored by the media, and obviously by doctors who are continually visited and educated by pharmaceutical companies.
Certainly, there are tens of thousands of studies reporting the benefits of varied nutritional supplements. They are both safe and effective. If doctors and the group were simply made aware of the poorly designed analyses that denigrate vitamin E supplementation, and the significant studies about the benefits of taking vitamin E, in the form of alpha-tocopherol and gamma-tocopherol (along with delta-tocopherol and the mixed tocotrienols) along with vitamin C and vitamin K, which replenishes the antioxidant abilities of vitamin E, then I believe that not only would people need less medication and sell out the economic urgency in the condition care industry, but more importantly people could enjoy the true condition and happiness that can be obtained by eating right, exercise, and permissible supplementation with a full spectrum of ability vitamins and minerals.
Vitamin E, in the natural form (as described above), appears to be safe up to at least 2000 Iu per day. I personally take 800 Iu per day of the full spectrum of vitamin E. When I was in medical practice, I recommended at least that much (if not up to 1200 Iu of vitamin E) to patients with diabetes. The natural form of vitamin E, along with co-enzyme Q10, the red grape extract (grape seed extract and resveratrol) and a full spectrum of other antioxidants (quercetin, alpha lipoic acid, turmeric extract, olive extract, green tea extract, etc.), vitamins (B, C, D, and K), and minerals in the chelated form, all contribute to safely and significantly sell out the risk of heart disease, stroke, cancer, Alzheimer's disease, lung diseases, and Almost every other continuing degenerative disease, as well as slow the aging process, all without the side-effects of drugs.
The Untold Epidemic - Vitamin E scantness
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