Each year hundreds of thousands of habitancy find themselves victim to some form of cancer. Caused by either environmental toxins or genetic disorders, the occurrence of cancer has risen in modern years. A report created by the National design of condition estimated the allembracing cost of cancer to be 3.8 billion in medical costs. This includes direct medical costs, morbidity costs, and indirect mortality costs. Since all forms of appropriate cancer rehabilitation are incredibly invasive (chemotherapy, radiation therapy, and surgery) and plagued with side effects, alternate methods of rehabilitation are always being sought after. One animated new selection is rehabilitation with Vitamin E tocotrienols. Some initial studies have been conducted showing the inherent for this vitamin in future cancer rehabilitation plans.
Tumor Growth
Vitamine
In order for a tumor to grow beyond 1 to 2 mm in diameter, it needs some sort of independent blood supply. Without this, the cancer tumor cannot spread and tumor increase stops. The creation of new blood vessels is termed angiogenesis. Tumors are able to publish increase factors that originate angiogenesis which causes existing blood vessels to originate new 'branches' that supplies the tumor with a blood supply.
Studies have shown that one of the mechanisms in which tocotrienols uses to prevent cancer metastasis is angiogenesis inhibition. Delta- and gamma- tocotrienols are especially mighty in this respect. The other form of vitamin E, tocopherols, do not show this ability.
Breast Cancer
Breast cancer ranks second as the cause of cancer death in women. Each year an estimated 275,000 new cases and almost 41,000 deaths occur in the United States. appropriate breast cancer rehabilitation involves the drug, Tamoxifen. Tamoxifen is a widely used hormone therapy. Although quite beneficial in treating breast cancer, tamoxifen does have its inherent risks. Long term rehabilitation with the drug increases a woman's occasion (albeit a rare chance) of developing serious condition problems: endometrial cancer, blot clot in the lungs, and blood clot in major veins.
Several studies have been done on tocotrienols quality to treat breast cancer. A 1998 publication in the Journal of food and Cancer confirmed that delta-tocotrienols are capable of inducing cell apoptosis (cell death). Other study published in the journal Bmc Cancer showed that gamma-tocotrienols in conjuncture with anti-cancer drugs cut breast cancer cell increase in mouse breast cancer cells in culture. Yet Other study showed that gamma-tocotrienols were able to prevent an implanted tumor from taking hold in a mouse specimen.
Prostate Cancer
Prostate cancer is most generally diagnosed cancer among men in the United States and the third most coarse cause of cancer death among men. Explore done by Davos Life Science, researchers at Australian Prostate Cancer Explore Center, and Hong Kong University showed that gamma-tocotrienols not only reduced tumour size, but also decreased the incidence rate of tumor formation by 75%. They compared this to a control group of mice, which had 100% tumor formation. This study is leading because prostate cancer stem cells (the precursor to the cancer tumor) is resistant to conventional chemotherapy drugs and thus very difficult to manage.
Pancreatic Cancer
Pancreatic Cancer causes 30,000 deaths per year in the United States. Pancreatic Cancer is a very potent cancer, with fewer than 5% of those diagnosed still alive five years after diagnosis. It is very rare and fortuitous for a unblemished remission of the disease to occur.
An animal study done by researchers at Md Anderson Cancer center have shows that combining gamma-tocotrienol with chemotherapy boosted the effectiveness of the drug in dealing with the tumor. In prostate cancer, the protein complex Nf-KappB is hijacked by the cancer cell. Nf-KappB usually controls our cellular response to stress and plays a key role in regulating the immune system. Once the tumor takes over Nf-kappB it starts using its same mechanisms to defend itself. Drugs that can selectively target Nf-kappB would be too toxic for our health. The only other available alternative for dealing with the tumor is with nutrition. Tocotrienols can differentiate in the middle of a cancer cell and a general cell and thus alter Nf-kappB accordingly.
A partial conjecture tocotrienols are sufficient against pancreatic cancer is because it can get in the pancreas 10x more than in other parts of the body such as the liver or even the tumor itself. Despite this accumulation, a study in mice was done to show that no observed toxicity or side effects occurred from delta-tocotrienol administration.
Other Cancers
Palm oil tocotrienol reduced cervical cancer in vitro. An in vivo and in vitro study showed suppresion of liver and lung carcinogenesis in mice. Gamma- and delta-tocotrienols were also shown to inhibit melanoma cancer cells in vitro.
Closing thoughts
The inherent for tocotrienols to act as a natural source to deal with cancer is very exciting. Of course, more human studies need to be done before they become a appropriate form of treatment. One last thing to note is that a multimillion dollar grant by the National Cancer design was recently awarded to the Moffitt Cancer center and Explore design to conduct clinical trials on tocotrienols' result on pancreatic cancer.
Can Vitamin E Tocotrienols Fight Cancer?
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